Fig. 6: The role of MDT in the partitioning of mitochondrial DNA nucleoids. | Nature Communications

Fig. 6: The role of MDT in the partitioning of mitochondrial DNA nucleoids.

From: ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation

Fig. 6

At the ER–mitochondria contact sites, nucleoids interact with the inner membrane protein complex MICOS. MICOS is associated with the outer membrane protein Miro1, which is concentrated at the ER–mitochondria contact sites and recruits KIF5B motors on the mitochondria. When KIF5B-driven dynamic tubulation happens, nucleoids are transported via the interaction axis of nucleoid/MICOS/Miro1/KIF5B.

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