Fig. 2: Induction of CD47 and HER2 in resistant BC cells and irradiated tumors.
From: Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
Expressions of HER2 and CD47 in radioresistant MDA-MB-231/C5 cells (a) in radioresistant MCF7/C6 cells (b) both were derived from surviving clones after FIR. c Expression of HER2 and CD47 in syngeneic mouse 4T1 breast tumors 16 h after local RT with single-dose radiation or FIR (pooled samples from six tumors). d Enhanced CD47+/HER2+ population in MCF7/C6 cells compared to parental MCF7 cells measured by flow cytometry (n = 3; *P < 0.05, ***P < 0.001, ****P < 0.0001). e Induction of CD47 by radiation in an array of human cancer cells (breast cancer MCF-7, BT474, SKBR3, glioblastoma U251, and colorectal carcinoma HCT116 cells) measured by immunoblotting 16 h after radiation (5 Gy). f Induction of CD47 expression in xenograft tumors (duplicated samples from each tumor group) following RT with fractionated doses (FIR, 2 Gy × 5).
