Fig. 5: Radiosensitization is maximized in mouse breast tumors carrying CD47−/−/HER2−/− status. | Nature Communications

Fig. 5: Radiosensitization is maximized in mouse breast tumors carrying CD47−/−/HER2−/− status.

From: Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells

Fig. 5

a Growth rate of mouse breast tumors generated with radioresistant 4T1/C2 cells with CD47−/−, HER2−/−, or CD47−/−/HER2−/−. b Representative images of tumors at the end of experiments. c Repeated experiment of a with a single dose IR (5 Gy) at day 9 and representative images of the tumor at the end of experiments shown in d; in a and c, n = 6, mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001. e Left, representative IHC images of CD11b+ macrophages in CD47−/−, HER2−/−, CD47−/−/HER2−/− tumors; scale bar = 100 µm; right, quantitation of CD11b+ macrophages (n = 4, *P < 0.05, ***P < 0.001).

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