Fig. 1: Cross-cancer genetic correlations (rg) calculated via LD-score regression (LDSC) and associated cancers from the locus-specific pleiotropy analysis.
From: Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
a Cancer pairs are connected if the genetic correlation had P < 0.05, width of the line is proportional to magnitude of rg, color of the line indicates direction of correlation (red is negative and blue is positive), and shading is proportional to strength of association according to P, where the Bonferroni-corrected threshold is 0.05/153 = 3.27 × 10−4; b cancer pairs are connected by a line (each line represents one region) if a region contains any SNPs associated with either cancer, where regions are formed around index SNPs with P < 5 × 10−8 for any cancer in the cancer-specific meta-analyses and SNPs are added if they have P < 5 × 10−8 for any cancer, are within 500 kb of the index SNP, and have LD r2 > 0.5 with the index SNP.
