Table 4 Top independent variants from the one-directional variant-specific pleiotropic analysis.
From: Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
SNP | Locus | P | OR | Associated cancer sites |
|---|---|---|---|---|
rs6587551 | 1q21.3 | 2.23 × 10−9 | 1.07 | Bl, Ki, Lu, Me, Pa, Pr |
rs1398148 | 1q32.1 | 2.82 × 10−10 | 0.92 | Bl, Ki, Me, Pr, Th |
rs2349073 | 2q33.1 | 3.78 × 10−18 | 1.09 | Br, En, Es, Le, Me, NHL, Ov, Pa, Te |
rs2293607 | 3q26.2 | 2.46 × 10−11 | 1.08 | Bl, Co, En, Es, Ki, Le, Me, Pr, Th |
rs148297846 | 5p15.33 | 2.42 × 10−8 | 0.86 | Bl, En, Ki, Lu, Pr |
rs130071 | 6p21.33 | 3.26 × 10−11 | 0.89 | Co, Es, NHL, Or, Re, Te |
rs2395191 | 6p21.32 | 5.93 × 10−10 | 0.85 | Le, NHL, Or, Th |
rs73728618 | 6p21.32 | 5.83 × 10−33 | 1.48 | Ce, NHL |
rs113661590 | 8q24.21 | 1.06 × 10−8 | 1.10 | Br, Es, Or, Pr, Re, Th |
rs6983267 | 8q24.21 | 7.52 × 10−74 | 1.24 | Co, Pr, Re |
9:21964331_CA_C | 9p21.3 | 2.08 × 10−8 | 0.92 | Br, En, Ki, Lu, Me, Or, Ov, Pa, Pr, Te, Th |
rs11813268 | 10q24.33 | 2.27 × 10−17 | 0.89 | En, Ki, Lu, Me, Or, Ov, Pr, Th |
rs78378222 | 17p13.1 | 2.20 × 10−12 | 0.72 | Es, Ki, Le, Me, Pa, Pr, Re |
rs11263763 | 17q12 | 3.78 × 10−47 | 0.82 | En, Pr, Te |
rs2532389 | 17q21.31 | 1.17 × 10−9 | 1.07 | Br, Ce, Lu, Me, Te |
rs4939827 | 18q21.1 | 2.65 × 10−10 | 1.15 | Co, Re |
rs34978822 | 20q13.33 | 8.21 × 10−10 | 1.34 | Bl, Le, Lu, Me, Pr, Th |
