Fig. 2: Comparative analysis of streptovaricins from wild-type strain and related mutants. | Nature Communications

Fig. 2: Comparative analysis of streptovaricins from wild-type strain and related mutants.

From: Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

Fig. 2

a LC–ESI–HRMS analysis of streptovaricins produced by wild-type strain and related mutants. The traces were extracted at calcd. m/z ([M + H]+) 770.33823, 772.35388, 726.34840, 728.36405, 754.34332, and 756.35897 corresponding to compound 1, 2, 3, 4, 5, and 6, respectively. The asterisks indicated no corresponding compounds were detected. b Chemical structures of streptovaricins from wild-type strain and related mutants. The structural differences among them are indicated with different colors. The MDB moieties are filled with red hexagons; their corresponding uncyclized parts are indicated with blue; different substitutions at C24 and C28 are indicated with magenta and orange, respectively. Experiments in a are representative of three independent experiments.

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