Table 3 Genome-wide significant associations (p_Discovery < 1.09 × 10⁻⁹) of global and regional CV.

From: Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Lobe	Region	Locus	Position	Lead SNP	Nearest gene	Annotation	N	p_Discovery
	Global	6q22.32	126792095	rs11759026	MIR588	Intergenic	22,410	6.31E−19
		17q21.31	44790203	rs169201	NSF	Intronic	22,784	2.11E−13
		17q21.32	43549608	rs149366495	PLEKHM1	Intronic	22,099	8.18E−13
		12q14.3	66358347	rs1042725	HMGA2	3’UTR	22,784	7.04E−11
		12q23.2	102921296	rs11111293	IGF1	Intergenic	22,784	5.45E−10
		6q22	109002042	rs4945816	FOXO3	3’UTR	22,784	8.93E−10
Frontal	Superior frontal	5q14.3	92186429	rs888814	NR2F1-AS1	Intergenic	22,692	3.29E−13
	Rostral middle frontal	15q14	39636227	rs17694988	C15orf54	Intergenic	22,793	3.15E−11
	Caudal middle frontal	2q12.1	105460333	rs745249	LINC01158	ncRNA_intronic	22,726	2.35E−11
	Caudal middle frontal	6q22.32	127068983	rs853974	RSPO3	Intergenic	22,351	4.82E−11
	Pars opercularis	5q23.3	128734008	rs12187568	ADAMTS19	Intergenic	20,753	4.27E−18
	Pars opercularis	15q14	39639898	rs4924345	C15orf54	Intergenic	22,758	1.97E−14
	Pars triangularis	3q24	147106319	rs2279829	ZIC4	UTR3	22,759	3.16E−23
		7q21.3	96196906	rs67055449	LOC100506136	Intergenic	22,759	4.03E−19
		15q14	39633904	rs2033939	C15orf54	Intergenic	22,759	8.49E−14
		7q21.3	96129071	rs62470042	C7orf76	Intronic	22,759	7.38E−13
		6q15	91942761	rs12660096	MAP3K7	Intergenic	22,759	4.74E−10
	Lateral orbitofrontal	14q22.2	54769839	rs6572946	CDKN3	Intergenic	22,801	2.29E−10
	Precentral	15q14	39634222	rs1080066	C15orf54	Intergenic	22,699	5.84E−125
	Precentral	10q25.3	118648841	rs3781566	SHTN1	Intronic	22,699	4.68E−11
Temporal	Superior temporal	3q26.32	177296448	rs13084960	LINC00578	ncRNA_intronic	22,681	1.12E−11
	Banksts	14q23.1	59072226	rs186347	KIAA0586	Intergenic	22,727	1.15E−15
	Fusiform	14q23.1	59833172	rs1547199	DAAM1	Intronic	22,605	4.58E−10
	Fusiform	1p33	47980916	rs6658111	FOXD2	Intergenic	22,605	7.78E−10
	Transverse temporal	2q23.2	150012936	rs2046268	LYPD6B	Intronic	22,786	2.55E−12
	Parahippocampal	2q33.1	199809716	rs966744	SATB2	Intergenic	22,747	2.23E−10
Parietal	Superior parietal	15q14	39633904	rs2033939	C15orf54	Intergenic	22,723	4.28E−23
		16q24.2	87225139	rs4843227	LOC101928708	Intergenic	22,723	1.16E−13
		19p13.2	13109763	rs68175985	NFIX	Intronic	21,777	3.27E−11
		5q15	92866553	rs62369942	NR2F1-AS1	ncRNA_intronic	21,664	4.32E−10
	Inferior parietal	20q13.2	52448936	rs6097618	SUMO1P1	Intergenic	22,701	2.09E−17
		12q14.3	65797096	rs2336713	MSRB3	Intronic	22,701	2.47E−13
		3q13.11	104724634	rs971551	ALCAM	Intergenic	22,701	2.34E−10
	Supramarginal	15q14	39632013	rs71471500	THBS1	Intergenic	22,645	9.71E−28
		14q23.1	59627631	rs2164950	DAAM1	Intergenic	22,645	3.59E−20
		3q24	147106319	rs2279829	ZIC4	UTR3	22,645	5.36E−18
	Postcentral	15q14	39633904	rs2033939	THBS1	Intergenic	22,662	4.34E−133
		3q24	147106319	rs2279829	ZIC4	UTR3	22,662	2.54E−17
		9q21.13	76144318	rs67286026	ANXA1	Intergenic	22,662	5.03E−11
		2q36.3	226563259	rs16866701	NYAP2	Intergenic	22,545	5.69E−11
	Precuneus	14q23.1	59628609	rs74826997	DAAM1	Intergenic	22,803	4.85E−20
		3q28	190663557	rs35055419	OSTN	Intergenic	22,428	2.02E−10
		2p22.2	37818236	rs2215605	CDC42EP3	Intergenic	22,803	3.43E−10
		3q13.11	104713881	rs12495603	ALCAM	Intergenic	22,803	9.71E−10
Occipital	Lateral occipital	14q23.1	59627631	rs2164950	DAAM1	Intergenic	22,799	6.89E−16
	Lingual	14q23.1	59625997	rs73313052	DAAM1	Intergenic	22,805	1.06E−20
	Lingual	6q22.32	127089401	rs2223739	RSPO3	Intergenic	22,805	1.75E−10
	Cuneus	14q23.1	59625997	rs73313052	DAAM1	Intergenic	22,799	4.59E−43
		11p15.3	12072213	rs11022131	DKK3	Intergenic	22,799	5.96E−12
		13q31.1	80192236	rs9545156	LINC01068	Intergenic	22,799	4.09E−10
	Pericalcarine	14q23.1	59628679	rs76341705	DAAM1	Intergenic	22,824	1.39E−29
		13q31.1	80191873	rs9545155	LINC01068	intergenic	22,824	2.25E−13
		11p14.1	30876113	rs273594	DCDC5	Intergenic	22,824	3.51E−13
		1p13.2	113208039	rs12046466	CAPZA1	Intronic	22,824	2.36E−12
		1p33	47980916	rs6658111	FOXD2	Intergenic	22,824	3.85E−11
		11q22.3	104012656	rs1681464	PDGFD	Intronic	22,824	7.51E−11
		6q22.32	127096181	rs9401907	RSPO3	Intergenic	22,824	2.11E−10
		7p21.1	18904400	rs12700001	HDAC9	Intronic	22,824	2.12E−10
		5q12.1	60315823	rs10939879	NDUFAF2	Intronic	22,824	2.92E−10
	Caudal anterior cingulate	5q14.3	82852578	rs309588	VCAN	Intronic	22,748	2.60E−10
	Insula	11q23.1	110949402	rs321403	C11orf53	Intergenic	22,543	9.58E−12
	Insula	8q24.12	120596023	rs10283100	ENPP2	Exonic	21,481	8.29E−11

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Table 3 Genome-wide significant associations (p_Discovery < 1.09 × 10⁻⁹) of global and regional CV.

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