Fig. 1: Loss of Xinβ results in alteration of the Hippo-YAP signaling pathway in the heart. | Nature Communications

Fig. 1: Loss of Xinβ results in alteration of the Hippo-YAP signaling pathway in the heart.

From: Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart

Fig. 1: Loss of Xinβ results in alteration of the Hippo-YAP signaling pathway in the heart.The alternative text for this image may have been generated using AI.

a Smear plot showing the log fold change and average abundance of each gene. Differentially expressed genes are marked red; the expression of Xinβ (also called Xirp2) is among the mostly downregulated in P7.5 (day 7.5) XinβKO hearts; b hierarchical clustering heatmap of differentially expressed genes; c gene set enrichment analysis (GSEA) with gene ontology gene-sets reveals molecular pathways related to cell proliferation and inflammation dysregulated in P7.5 XinβKO hearts; d qRT-PCR of cell-cycle-related genes in P7.5 XinβKO and control hearts. N = 4 biologically independent samples, *P < 0.05. e qRT-PCR of genes related to immune and inflammatory response in P7.5 XinβKO and control hearts. N = 4 biologically independent samples, *P < 0.05. f Enrichment plot showing downregulation of the YAP-conserved pathway; g qRT-PCR of YAP pathway genes in P7.5 XinβKO and control hearts. N = 4 biologically independent samples, *P < 0.05. h Workflow of comparative analysis of dysregulated genes between XinβKO hearts and Ad-YAP cardiomyocytes; i GSEA with MSigDB Hallmark gene sets (v 6.2) displaying differentially regulated pathways between XinβKO hearts and Ad-aYAP cardiomyocytes.

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