Fig. 4: AzTax3MP leads to dose- and light-dependent cell-cycle arrest. | Nature Communications

Fig. 4: AzTax3MP leads to dose- and light-dependent cell-cycle arrest.

From: Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Fig. 4

a Flow cytometry analysis of cell-cycle repartition shows that AzTax3MP leads to a light-dependent shift of living cells towards G2/M phase. b, c The cell-cycle distribution of AzTax-treated cells approaches that of docetaxel-treated cells in a dose- and light-dependent manner. HeLa cells treated under light/dark conditions for 24 h (d indicates dark and λ indicates lit conditions; pos. indicates docetaxel control at 0.1 µM; n = 3 biologically independent experiments, except n = 4 for 0.75 µM AzTax3MP and n = 5 for cosolvent and docetaxel controls; data shown as mean with s.d.).

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