Fig. 8: The impact of rs181766 on lincNORS promoter activity.
From: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
a List of physical traits that are reported as significantly associated with rs181766 in UK Biobank (https://genetics.opentargets.org/). b The effect of two selected SNPs rs246185, rs181766 on lincNORS expression was examined using luciferase assay. A diagram displaying the lincNORS promoter cloning was shown on the right. Data represent mean + SD from 4 to 11 biological replicates (*p < 0.05, ***p < 0.005, one-way ANOVA followed by Dunnett’s multiple comparisons test against REF). c eQTL boxplot showing genotype-expression relationships between rs181766 and lincNORS (top) or the closest protein-coding gene MKL2 (bottom).
