Fig. 1: Dimensionality reduction of samples and periodic features.

Principal component analysis (PCA) of samples based on skeletal muscle genes (a), skeletal muscle metabolites (b), and serum metabolites (c), with color indicating sampling time. Circle indicates extended feeding (EXF), and triangle indicates time-restricted feeding (TRF). t-SNE clustering of periodic transcripts in skeletal muscle after EXF (d), and TRF (e). Periodic metabolites in skeletal muscle after EXF (f), and TRF (g), and serum metabolites after EXF (h), and TRF (i). n = 11 participants.