Table 2 Primary outcomes in all and older participants (age ≥ 50 years).
From: Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
HbA1c 0 w (%) | HbA1c 13 w (%) | Change in HbA1c (95% CI)a | Change in HbA1c (95% CI)b | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|---|---|
P-valuec | P-valued | P-valuec | P-valued | ||||||
All participants | |||||||||
Plac | 7.81 ± 0.81 | 7.23 ± 0.97 | −0.59 (−0.75, −0.44) | / | 5.99E − 04 | / | 6.31E − 04 | ||
Prob | 7.78 ± 0.82 | 7.27 ± 0.90 | −0.53 (−0.68, −0.37) | 0.07 (−0.20, 0.34) | 0.53 | 5.15E − 05 | 0.52 | 5.11E − 05 | |
BBR | 7.68 ± 0.76 | 6.71 ± 0.77 | −0.99 (−1.16, −0.83) | −0.40 (−0.67, −0.13) | 5.99E − 04 | / | 6.31E − 04 | / | |
Prob + BBR | 7.66 ± 0.82 | 6.62 ± 0.66 | −1.04 (−1.19, −0.89) | −0.44 (−0.71, −0.18) | 8.41E − 05 | 0.70 | 6.99E − 05 | 0.66 | |
Age ≥ 50 years | |||||||||
Plac | 7.76 ± 0.77 | 7.24 ± 1.13 | −0.59 (−0.78, −0.39) | / | 0.03 | / | / | ||
Prob | 7.64 ± 0.69 | 7.07 ± 0.61 | −0.52 (−0.72, −0.33) | 0.06 (−0.26, 0.39) | 0.65 | 8.65 E − 03 | / | / | |
BBR | 7.58 ± 0.69 | 6.82 ± 0.81 | −0.90 (−1.10, −0.70) | −0.31 (−0.65, 0.02) | 0.03 | / | / | / | |
Prob + BBR | 7.61 ± 0.73 | 6.62±0.57 | −0.99 (−1.17, −0.82) | −0.41 (−0.72, −0.09) | 2.39E − 03 | 0.48 | / | / | |
