Fig. 5: Visualizing the glycan crown of HKU1 HE lectin domain. | Nature Communications

Fig. 5: Visualizing the glycan crown of HKU1 HE lectin domain.

From: Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

Fig. 5: Visualizing the glycan crown of HKU1 HE lectin domain.The alt text for this image may have been generated using AI.

a Top down view of the dimeric BCoV HE lectin domain, shown as a surface representation and coloured according to sequence conservation (67 sequences). N-linked glycosylation sites are labelled, coloured orange and, if modelled, shown as spheres. The sialic acid binding site is circled and esterase active site is indicated by an asterisk. b Equivalent view as shown in A for HKU1 HE (40 sequences). c The same view as shown in B overlaid with the HKU1 HE N-linked glycan EM difference density, coloured orange. d Side view of BCoV HE and (e–f) HKU1 HE, depicted as in (a–c). The most membrane distal region of BCoV and HKU1 HE is indicated by a dashed line.

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