Fig. 5: Evidence supporting/contradicting SARS-CoV antibody-related pathogenesis. Supporting evidence given in red and contradicting evidence in blue.
Weaker evidence (speculation in discussions) shown in gray, evidence from in vitro studies in thin lines, and evidence observed in humans in thick lines. Anti-S1 antibodies triggered upon infection may facilitate entry into immune cells at later stages of the infection if concentration is low. Replication happens but no virus is released. Consequential induction of cytokines is inconclusive, but if they occur, they are associated with severe disease. Roles of anti-S2 and anti-N antibodies are supported by binding observations.
