Fig. 7: Age-seroincidence curves under four models of coronavirus immunity. | Nature Communications

Fig. 7: Age-seroincidence curves under four models of coronavirus immunity.

From: A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Fig. 7: Age-seroincidence curves under four models of coronavirus immunity.

Each curve displays the age seroincidence for a single endemic strain. The four hypothetical models of coronavirus immunity are (1) infection grants lifelong, complete homologous immunity (red), (2) infection grants complete homologous immunity for 5 years, then reversion to complete susceptibility (green), (3) infection grants lifelong homologous immunity at 50% efficacy (cyan), and (4) the strain consists of four antigenically diverse genotypes, each granting complete homologous immunity within genotype, but no cross-protection between genotypes (blue). Confidence bands represent uncertainty in the force of infection as estimated from the seroprevalence data.

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