Fig. 6: Comparison of viral polymerase active site structures and sequences. | Nature Communications

Fig. 6: Comparison of viral polymerase active site structures and sequences.

From: Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Fig. 6: Comparison of viral polymerase active site structures and sequences.The alternative text for this image may have been generated using AI.

a Analogous post-catalysis, pre-translocation structures of CoV nsp12 and poliovirus 3Dpol after incorporation of remdesivir (RDV) and deoxycytosine (dCYT), respectively. The CoV polymerases have replaced a motif F glutamate residue (3Dpol Glu161) with an alanine (nsp12 Ala547), removing a highly conserved interaction that positions the motif F arginine for interactions with the NTP and pyrophosphate. b Alignment of representative viral RdRp sequences showing the large genome nidoviruses have a SDD instead of GDD sequence in the palm domain motif C (tan) and alanine, serine or glutamine in place of the aforementioned glutamate (blue) found in other positive strand RNA viruses. The NTP-interacting arginine (yellow) is conserved, but the overall length of the motif F loop is shorter in the nidoviruses (numbers reflect omitted residues).

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