Fig. 1: Generation of combinatorial binder/format bsAb matrices via dummy-Fc driven assembly. | Nature Communications

Fig. 1: Generation of combinatorial binder/format bsAb matrices via dummy-Fc driven assembly.

From: Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices

Fig. 1: Generation of combinatorial binder/format bsAb matrices via dummy-Fc driven assembly.

a Affinity tag-containing dummy chains drive bsAb assembly and enable one-step purification. b Combination of educts of different formats generates bsAb format diversity. Green circles indicate the location of paratopes in output formats. c Combining binders in different input formats multiplies the binder–format design space. Each product within the matrix is a unique bsAb with a specific binder combination in a specific format.

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