Fig. 3: Muscle-specific Btl-dERK signalling promotes muscle wasting in HSD.
From: Systemic muscle wasting and coordinated tumour response drive tumourigenesis
a Circulating haemolymph levels of upregulated amino acids in LacZ (blue bars) and ras1G12V;csk−/− (red bars) animals raised on HSD compared to animals raised on CD. Results are shown as mean ± SEM. Data from n = 4 biologically independent samples. F-actin (red) staining of dissected larval body-wall muscle tissue from mhc > LacZ (b), mhc > btl.λ (c), mhc > rlSEM (d), and mhc > btl.λ, rlRNAi/TRiP31387 (e) third-instar larvae raised on HSD. Scale bar, 100 μm. f Matching body-wall muscle wasting quantification. g Matching haemolymph proline quantification. Results are shown as mean ± SEM. Data from n = 4 biologically independent samples. Data were analysed by two-tailed unpaired Student’s t test. Asterisks indicate statistically significant difference (*P < 0.05).
