Fig. 5: ASD genetic risk variant enrichments. | Nature Communications

Fig. 5: ASD genetic risk variant enrichments.

From: Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

Fig. 5

a Partitioned heritability enrichments for ASD, Alzheimer’s, and IBD GWAS in differentially expressed, methylated, or acetylated regions of the genome. Uncorrected p-values < 0.05 are shown. P-values were also adjusted for multiple testing by FDR correction and those enrichments with adjusted p-value < 0.1 are marked with asterisks. b Partitioned heritability enrichments for ASD, Alzheimer’s, and IBD GWAS in differentially acetylated regions of the genome within, or distal to, gene promoters. Uncorrected p-values < 0.05 are shown. P-values were also adjusted for multiple testing by FDR correction and those enrichments with adjusted p-value < 0.1 are marked with asterisks. c Top 30 hub genes and 300 connections for co-expression module mRNA.M4. d Top gene ontology enrichments for co-expression module mRNA.M4. Ontology enrichments were calculated by g:Profiler with FDR corrected p-values. e, f Genomic region around DMTN e and STX1B f. ASD-associated hyperacetylated regions are shown along with eQTL and Hi-C linkages to the gene TSS.

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