Fig. 2: Patterns of selection at the ASIP locus.

a XP-EHH scores across the ASIP locus as viewed in the BOmA browser (https://tinyurl.com/boma-asip). The location of the non-synonymous ASIP variant is indicated by a vertical orange line spanning all tracks. The elevated XP-EHH scores at this locus in comparisons involving the Murrah breed is shown. Low absolute XP-EHH scores are shown in blue with high scores in red. b Patterns of XP-EHH across all breed comparisons. Each column in the heatmap represents a different variant in the region, ordered according to their location in the genome. The intensity of colour indicates the variant’s XP-EHH score and the location of the ASIP gene is indicated by the dashed vertical lines. The distribution of absolute XP-EHH scores in each breed comparison across the region are indicated by the violin plots. c The location of the arginine to cysteine change in the cysteine rich agouti domain of ASIP. The location of the five disulphide bonds are indicated in both the predicted 3D structure and sequence below. The blue, orange and green boxes below the sequence indicate the locations of the N-terminal loop, active loop and C-terminal loop, respectively. The source data for panels (a) and (b) can be downloaded from the BOmA website.