Fig. 6: FOXP3+ T cells in IL-33-expressing tumors. | Nature Communications

Fig. 6: FOXP3+ T cells in IL-33-expressing tumors.

From: Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Fig. 6: FOXP3+ T cells in IL-33-expressing tumors.

Shown are representative IHC (brown) for IL-33, CD4, and FOXP3 in a primary GBM specimens (CD4 N = 5; FOXP3 N = 5), b syngeneic K1492-control and IL-33+ mouse glioma (CD4 N = 6; FOXP3 N = 6), and c PDGFB, PDGFA, and shNF-1/Cre-driven glioma (CD4 N = 3, FOXP3 N = 3). Sections were counterstained with hematoxylin (blue). Scale bars: 20 µm. d Graph shows the quantitation of CD4+ (upper panel) and FOXP3+ (lower panel) cells present in K1492-control (N = 6) or IL-33+ (N = 6) xenografts. Mice injected with PBS were used as sham controls (N = 3). Results are expressed as the mean ± SEM of the percentage of positive cells/whole brain section (K1492-control and IL-33+ 6 mice/group; sham control 3 mice/group); *p ≤ 0.05 by one-way ANOVA with Tukey’s post hoc test. Source data are available as a Source data file.

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