Fig. 2: PD-L1 on DCs is essential for the response to PD-L1 blockade therapy. | Nature Communications

Fig. 2: PD-L1 on DCs is essential for the response to PD-L1 blockade therapy.

From: PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

Fig. 2: PD-L1 on DCs is essential for the response to PD-L1 blockade therapy.The alternative text for this image may have been generated using AI.

a MC38 tumors established in CD11c-cre;Pdl1fl/fl (n = 5) or control mice (n = 4 IgG, 5 anti-PD-L1) were treated with IgG or anti-PD-L1 on day 8 and 12. Tumor growth curves were shown. ***p = 0.0007. b WT (n = 4 IgG, 5 anti-PD-L1) or Batf3−/− mice (n = 3 IgG, 4 anti-PD-L1) were inoculated with 5 × 105 MC38 cells. Mice were treated with IgG or anti-PD-L1 on day 8 and 12. Tumor growth curves were shown. ***p < 0.0001. Data are shown as mean + SEM and are representative of two independent experiments. n.s., not significant; ***p < 0.001 determined by two-way ANOVA. Source data are provided as a Source Data file.

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