Fig. 5: DMA-135 changes the local and global structure of SLII. | Nature Communications

Fig. 5: DMA-135 changes the local and global structure of SLII.

From: IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

Fig. 5

a Superimposition of 10 lowest energy SLII-(DMA-135) complex structures refined in AMBER using NOE-derived distance restraints and RDCs. The overall RMSD for the stably base paired regions is 2.4 Å. b Comparison of the bulge stacking interactions of (left) free SLII to that of the SLII-(DMA-135) complex (right). c Correlation plot between measured and back-calculated RDCs from a representative low energy SLII-(DMA-135) structure and to back-calculated RDCs from the free SLII structure. d Superimposition of the lower helices of free and bound SLII reveals that DMA-135 induces a global change to the SLII structure.

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