Fig. 1: Unique mutation feature of Brca1-deficient breast tumors revealed by bulk WES. | Nature Communications

Fig. 1: Unique mutation feature of Brca1-deficient breast tumors revealed by bulk WES.

From: Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Fig. 1

a Mutation types in the coding exon region of Brca1-deficient breast tumors (n = 23 tumors). b Mutational signature in Brca1-deficient breast tumors (n = 23 tumors). Mutational signature was generated using all SNVs detected in samples. c Oncoplot summarizing all altered genes with nonsynonymous SNVs in Brca1-deficient breast tumors of Brca1MKO mice (n = 23 tumors). PT-primary tumor, LMT-liver metastatic tumor, 5L-tumor in 5th left mammary gland, 5R-tumor in 5th right mammary gland, WT-wild type, +/∆-deletion of one allele of exon 5 and 6 of p53 mediated by Wap-Cre-LoxP, LOH/∆-deletion of two alleles of p53, one allele deletion is mediated by Wap-Cre-LoxP, another one is naturally lost. d Oncoplot summarizing all altered TSGs or oncogenes with nonsynonymous SNVs in breast tumors of patients with BRCA1 germline mutation from the WSI dataset (n = 31 tumors). e CNV profiles of Brca1-deficient breast tumors of Brca1MKO mice (n = 23 tumors).

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