Table 1 Potential driver genes in each tumor.

Group	p53 status	Sample	Driver genes	TSG/oncogene	VAF	Days^e
Brca1co/co; MMTV-Cre	Wild type	476PT	Adam20	PRE-TSG	0.33	402
			Prdm2	TSG	0.26
			Ttn	PRE-TSG	0.23
			Ttc28	PRE-TSG	0.21
			Kansl2	PRE-TSG	0.21
		153PT	Arhgef11	PRE-TSG	0.37	440
			Pbrm1	TSG	0.33
			Ipo7	PRE-TSG	0.24
			Psip1	Oncogene	0.21
		153LMT	Plekha5	PRE-TSG	0.52
		153LMT	Arhgef11	PRE-TSG	0.28
		1867-5L	Esrp1	TSG	0.12	673
		1949-3L	Aff3	Oncogene	0.37	651
			Kdr	Oncogene	0.13
			Cyb5a	TSG	0.07
	Frameshift	1949-5R	Trp53	TSG	0.87	651
			Rasal1	TSG	0.46
			Hspd1	TSG	0.06
		958-5L	Trp53	TSG	0.82	929
		958-5L	Mms22l	Oncogene	0.14	929
Brca1co/co; p53+/co; Wap-Cre	'+/△^a	2307-2R	Rere	Oncogene	0.33	342
			Tpr	Oncogene	0.12
			Cars	TSG	0.09
			Rsf1	Oncogene	0.06
		2307-5R^c	Ptch1	TSG	0.16	342
		2307-5R^c	Birc3	Oncogene	0.01	342
		2313-2L	Kras	Oncogene	0.41	342
			Ralgds	Oncogene	0.31
			Ptprb	TSG	0.12
			Ranbp9	TSG	0.05
		2384-5R	Rps6kb1	^d	0.52	307
		2388-3R^c	Stx3	PRE-TSG	0.04	330
	'LOH/△^b	2303-5R	Abcg2	TSG	0.40	371
		2303-5R	Atm	TSG	0.03	371
		2305-4L	Nras	Oncogene	0.80	342
		2306-2R^c	Top1	PRE-TSG	0.12	342
		2313-3R^c	Birc6	Oncogene	0.29	342
			Smarce1	TSG	0.18
			Traf6	Oncogene	0.17
			Sf3b1	Oncogene	0.04
		2313-4R	Rassf4	TSG	0.15	342
		2313-4R	Akt3	Oncogene	0.03	342
		2318-3R	Map4k1	TSG	0.37	365
			Slit2	TSG	0.33
			Yy1	Oncogene	0.31
			Slx4	TSG	0.21
			Prkcb	TSG	0.05
			Vegfa	TSG/oncogene	0.04
		2321-3L	Lad1	^d	0.39	342
		2321-3L	Adh5	PRE-TSG	0.07	342
		2378-1L	Csmd1	TSG	0.41	330
			Apc	TSG	0.39
			Egfr	Oncogene	0.14
		2384-2R^c	Dlx5	Oncogene	0.07	307
		2404-3R	Nf1	TSG	0.86	326
		2404-3R	Shprh	TSG	0.18	326

^aDeletion of one copy of exon 5 and 6 of p53 mediated by Wap-Cre-LoxP.
^bDeletion of two copies of exon 5 and 6 of p53. One copy deletion is mediated by Wap-Cre-LoxP, another one is naturally lost.
^cThe driver mutations in this tumor cannot be validated by Sanger sequencing.
^dThe gene is neither a TSG/oncogene nor a PRE-TSG/Oncogene but with high VAF.
^eDays to observe tumors.

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