Fig. 1: Overview of the genomic alterations correlated to chemotherapy response. | Nature Communications

Fig. 1: Overview of the genomic alterations correlated to chemotherapy response.

From: Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Fig. 1: Overview of the genomic alterations correlated to chemotherapy response.

a Oncoplot showing the significantly mutated genes in 165 tumors annotated by exome coverage, mutation load stratified by impact (as defined by SnpEff) and mutational signature deconvolution (top panels) and by clinical response, neoantigen load, number of damaging mutations in DDR genes, percentage of genome in allelic imbalance, expression subtypes, regulon cluster, RNA immune score, hypermethylation cluster and immune phenotype (bottom panel). b–e Violin plots showing the total number of SNVs, indels, neoantigens or the percentage of the genome in allelic imbalance compared to chemotherapy response. f Presence of damaging DDR mutations compared to chemotherapy response. g–i Violin plots showing the total number of SNVs, indels or the percentage of the genome in allelic imbalance compared to the two main mutational subtypes. j Presence of DDR mutations compared to the two main mutational subtypes. k Mutational subtypes compared to chemotherapy response. All p-values were calculated using a Wilcoxon rank-sum test for continuous variables and a Fisher’s exact test for categorical variables. Source data are provided as a Source data file.

Back to article page