Fig. 7: Graphic schematization of possible PARG-1 modes of action. | Nature Communications

Fig. 7: Graphic schematization of possible PARG-1 modes of action.

From: Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Fig. 7

a PARG-1 associates with the SC through its binding with HTP-3 independent of its enzymatic proficiency. b Loading of PARG-1 is necessary for efficient formation of recombination intermediates, and c to shape the recombination landscape, to prevent unscheduled CO occurrence and weakening of CO interference. d Through cooperation with HIM-5, PARG-1 ensures normal levels of DSBs, and their legitimate repair via HR by influencing the global numbers of inter-homologue recombination intermediates and their chromosome-wide location. This ultimately ensures maintenance of synapsis.

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