Fig. 5: Oxidative stress during latency.
From: Mycobacterium tuberculosis progresses through two phases of latent infection in humans
The proportion of mutations (y-axis) is shown for each mutation type (x-axis) for early (reactivation within 2 years, shaded bars) and late (reactivation after 2 years, black bars) latency. The incidence of mutations due to oxidative stress (cytosine deamination: C>T, G>A; and 8-oxoguanine: G>T, C>A) are indistinguishable in early and late latency. The number of mutations in early latency (years [0,2]) are: C>T: 4, G>A: 4, G>T: 1, C>A: 1, G>C: 1, C>G: 1, T>C: 1, T>A: 0, T>G: 2, A>C: 1, A>T: 0, A>G: 0. The number of mutations in late latency (years (2,6]) are: C>T: 8, G>A: 8, G>T: 1, C>A: 4, G>C: 7, C>G: 1, T>C: 1, T>A: 1, T>G: 1, A>C: 1, A>T: 2, A>G: 3. Source data are provided as a Source Data file.
