Fig. 4: Identification of signaling pathways and genes in cortical neuronal subtypes that might underlie seizure activity. | Nature Communications

Fig. 4: Identification of signaling pathways and genes in cortical neuronal subtypes that might underlie seizure activity.

From: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Fig. 4: Identification of signaling pathways and genes in cortical neuronal subtypes that might underlie seizure activity.The alternative text for this image may have been generated using AI.

a The total number of enriched DE genes for GO terms “action potential”, “glutamate receptor signaling pathway”, and “AMPA glutamate receptor complex” in each neuronal subtype. b–d Expression level of DE genes found in the GO terms “action potential”, “glutamate receptor signaling pathway”, and “AMPA glutamate receptor complex”, respectively, ordered by neuronal subtype. The color of the points represents Z scores of differential expression between conditions, with the blue color showing downregulation and red colors indicating upregulation of gene expression in epilepsy. The size of the points corresponds to the average expression level of a gene in a given cluster. Points with low Z scores have higher transparency.

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