Fig. 6: Layer-wise dysregulation of gene expression of glutamate receptor subunits in the cortex of epileptic patients. | Nature Communications

Fig. 6: Layer-wise dysregulation of gene expression of glutamate receptor subunits in the cortex of epileptic patients.

From: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Fig. 6: Layer-wise dysregulation of gene expression of glutamate receptor subunits in the cortex of epileptic patients.

a Overview of a brain section showing DAPI labeling that was used for identification of the cortical layers. b–d Representative images of the temporal cortices of control (nonepileptic) and epileptic brains showing an increased number of mRNA molecules for GRIA1 in L2–3 (b), GRIA1 in L5–6 (c), and GRIN3A in L5–6 (d). e–g Quantifications showing the increase of mRNA molecules in the epileptic temporal cortex for GRIA1 in L2–3 (e: one-tailed Mann–Whitney test, 136 cells in three sections from three control brains and 113 cells in three sections from three epileptic brains), GRIA1 in L5–6 (f: one-tailed Mann–Whitney test, 145 cells in three sections from three control brains, and 117 cells in three sections from three epileptic brains) and GRIN3A in L5–6 (g: one-tailed Mann–Whitney test, 130 cells in two sections from two control brains and 143 cells in three sections from three epileptic brains).

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