Fig. 7: Dysregulation of genes underlying hypoinhibition in the cortex of epileptic patients. | Nature Communications

Fig. 7: Dysregulation of genes underlying hypoinhibition in the cortex of epileptic patients.

From: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Fig. 7: Dysregulation of genes underlying hypoinhibition in the cortex of epileptic patients.The alternative text for this image may have been generated using AI.

a, b Visualization of GAD1 and GAD2 expression to assess hypoinhibition of GABAergic interneurons revealed a general decrease in expression of these genes involved in GABA synthesis. Total-count normalized expression level is shown on the y axis. Points represent median expression values, averaged over all samples for each subtype. Whiskers show 25 and 75% levels of expression, also averaged over all samples. c Decreased expression of cannabinoid receptor 1 (CNR1) in Vip and Id2 non-Lamp5 subtypes. d Representation image showing smFISH analysis of CNR1 transcript abundance in VIP-positive GABAergic interneurons in a nonepileptic cortex. e Quantitative analysis of CNR1 transcript abundance by smFISH demonstrating a decrease in CNR1 expression in VIP-positive GABAergic interneurons in epileptic cortex (one-tailed unpaired t test, 22 cells in three sections from three control brains and 43 cells in five sections from five epileptic brains).

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