Fig. 5: Identifying key regulators based on local TF connectivity.
From: Reconstructing the maize leaf regulatory network using ChIP-seq data of 104 transcription factors
a The chlorophyll biosynthesis pathway. The genes encoding key enzymes for each step are shown below the arrow. The widths of the edge between TF and gene represent regulatory potential based on the TIP model. The 104 TF nodes are represented as circles and grouped into 7 modules, with size proportional to the sum of the regulatory potential. b The maize photosynthetic carbon pathway. Key genes encoding enzymes responsible for CO2 fixation and transport between mesophyll and bundle sheath cells are shown. c Heatmap showing the expression gradient of core C4 photosynthesis genes in four leaf sections from base to tip, as well as their mesophyll and bundle sheath cell-specific expression patterns. d Pale-green leaf and seedling lethal phenotypes of the COL8 CRISPR/Cas9 mutant. e Cell-type specific H3K27me3 in core C4 gene loci. MC mesophyll cells, BS bundle sheath cells. Source data underlying Fig. 5c are provided in a Source Data file.
