Fig. 5: The combination of AUR and COL shows potency in vivo.
From: Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin
a, b Balb/c mice were given a sublethal dose of K. pneumoniae 9607 (MCR-1+) and received single dose of i.p. administration of vehicle, AUR, COL or their combination (n = 4 per group). Bacterial loads in the spleen (a) and liver (b) are shown. c Survival curves showing combination efficacies in the peritonitis infection model. Balb/c mice were infected by a lethal dose of E. coli CKE (MCR-1+, NDM-5+) and received single dose of i.p. administration of vehicle, AUR, COL or their combination (n = 6 per group). a, b Error bars represent mean ± SEM for biological replicates. a, b P values were determined by an unpaired two-tailed student t-test with Welch’s correction. For a P < 0.0001, significance difference between AUR + COL and Vehicle or AUR group, P = 0.0006, significance difference between AUR + COL and COL. For b, a P < 0.0001, significance difference between AUR + COL and Vehicle or AUR group, ***P = 0.0002, significance difference between AUR + COL and COL. c P values were determined by two-tailed Log-rank (Mantel–Cox) test. P = 0.0004, significance difference between AUR + COL and vehicle group, P = 0.0005, significance difference between AUR + COL and AUR group, P = 0.0183, significance difference between AUR + COL and COL group. Source data are provided as a Source Data file.
