Fig. 2: Establishing a chem-biosynthesis method for potential SGLT2 inhibitors. | Nature Communications

Fig. 2: Establishing a chem-biosynthesis method for potential SGLT2 inhibitors.

From: Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides

Fig. 2: Establishing a chem-biosynthesis method for potential SGLT2 inhibitors.

a The redesigned structures of the substrates and corresponding glycosylated products. b Conversion rate of each substrate with purified AbCGT. c Conversion rate of each substrate with whole-cell system. *Not reported C-glycosides previously. ND not detected. Experiments were performed at 30 °C in M9 medium for 12 h with shaking (200 rpm), and the conversion rates represent mean ± SD of three independent replicates (n = 3).

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