Fig. 4: Proteins that physically interact are specifically enriched for covariations at the RNA level. | Nature Communications

Fig. 4: Proteins that physically interact are specifically enriched for covariations at the RNA level.

From: Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

Fig. 4: Proteins that physically interact are specifically enriched for covariations at the RNA level.The alternative text for this image may have been generated using AI.

a Genes that interact on the protein level are highly enriched for covariations. Covariation enrichment of genes that are annotated to be interacting on the protein level according to the STRING database. b Covariations enrichment for genes whose protein products are part of the same physical complex and for genes that are part of the same reaction (pathway). c Gene covariations are mainly driven by protein interaction. Covariation enrichment of genes sharing the same GO annotation or KEGG pathway annotation. GO and KEGG annotations are stratified into pairs with shared annotation and experimentally identified protein interaction (+PI) and shared annotation but lack of experimentally identified protein interaction (−PI). d Model. Heteromeric protein complexes require proper stoichiometry of protein components. Proteins that are in surplus can be degraded, misfolded or form aggregates.

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