Fig. 6: Multivalent interactions comprise the SIRT6:nucleosome interaction.
From: Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6
The nucleosome core particle is shown in surface representation and the SIRT6 structure (residues 13–296) is in cartoon. Under the simplest model, each acidic patch on either side of the nucleosome supports binding to one SIRT6 molecule, depicted here with purple residues representing the most protected peptides in HDX analysis (Fig. 2c). The CTD is necessary for interactions with nucleosomal DNA at the higher affinity site.
