Fig. 6: Orthotopic hepatocellular carcinoma (HCC) model theranostics by encapsulin-produced magnetic iron oxide nanocomposites (eMIONs).
From: Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics
a Schematic illustration of animal therapy by eMIONs. b Orthotopic HCC model verified and multimodality imaging-guided eMION delivery. c Semiquantitative analysis of magnetic resonance imaging (MRI) before/after eMIONs injection. Data are presented as mean ± SD (n = 3 biologically independent mice). d Bioluminescence imaging of LM3 tumors in response to eMIONs treatment with/without alternative magnetic field (AMF). e, f Growth curves for tumors (e) and body weight changes of mice (f) with different treatments. Data are presented as mean ± SD (Group PBS and eMIONs, n = 3 biologically independent mice, and group eMIONs + AMF, n = 5 biologically independent mice). g, h Representative orthotopic HCC (g) and H&E stain results at 2 weeks after therapy (h). Scale bar of the above pictures: 500 μm; scale bar of neither pictures: 200 μm. i Liver function was detected 2 weeks after therapy. j Survival curves of mice after therapy (n = 5 biologically independent mice). Statistical significance was calculated with two-tailed Student’s t test (P = 0.047), and * indicated that P < 0.05.
