Table 1 SNR enhancements ε extracted upon comparing the various 2D HMT and conventional NOESY and TOCSY spectra collected in this study, for the acquisition times indicated in the corresponding Figures.

From: Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids

Biomolecule (labile group)

SNR enhancements ε calculated at the specific chemical shifts (ppm, top rows)

εaverage$

\(\frac{{\varepsilon _{{\mathrm{average}}}}}{{{\mathrm{unit}}\,{\mathrm{time}}}}\)

Sugars (OH)

Myo-In

5.5

3–10

5.6

3–10

5.8

4–10

5.9

>10#

–

–

~8

~170

(SiA)4 NOESY

5.1

>10#

5.3

2–5

5.5

>10#

5.9

>10#

6.1

6

6.3

4

~9

~50

(SiA)4 TOCSY

5.1

>10#

5.3

2.3–10

5.4

1.1–6

5.5

2.4–10

6.0

8

6.1

5–12

~6

~192

Protein (NH)

LA5

6.7

1–1.7

7.3

1–2

8.0

1.7–2.8

8.3

1.8–2.2

8.8

1.2–2.8

8.9

1.7

~1.8

~10

Protein (OH)

Ubiq

5.8

1.6–5.1

7.4

1.2–2

7.5

1.7–4

7.6

2–3.3

7.8

5

7.9

4.5

~3

~60

RNA (NH)

14mer 1 GHz

10.9

>10#

11.7

>10#

12.7

3–7

12.9

5–10

13.2

2.5–4.5

13.8

4–7

~7

~224

14mer 600 MHz

10.9

>5

10.9

>5

12.7

3–6

12.9

2.5–5

13.2

2–3.5

13.8

2.5–4

~4

~85

  1. Summarized as well are the average SNR enhancements/unit_time for the different compounds.
  2. #Cross-peak not detected altogether in conventional experiments; a minimum 10-fold enhancement is assumed.
  3. $εaverage: average enhancements (ε1+ε2+ε3+⋯+εN)/N calculated for N peaks in spectrum.
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