Fig. 6: Clonal selection in response to FLT3 inhibitor-containing therapy.
From: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
A 74-year-old man with newly diagnosed therapy-related acute myelomonocytic leukemia showing a selection of FLT3 p.D835Y clone during a FLT3 inhibitor-containing therapy. The fish plot shows the inferred clonal evolution pattern based on the single-cell genotype data. The phylogenetic trees visualize the estimated order of mutation acquisition and the proportion of subclones with a different combination of mutations at each timepoint. The wild-type cells which did not carry any driver mutations are not shown. BL baseline, CR complete remission, C cycle, D day, REL relapse, ADO allele dropout, FPR false-positive rate. Full case description is available in Supplementary Methods.
