Fig. 4: Intact discrimination between threat and safety cues, but elevated baseline responding and slowed stress recovery, following sgACC/25 over-activation.
Gray = control, orange = over-activation. Shading and error bars represent SEM. BL indicates baseline (20s pre-CS). n = 7. a sgACC/25 over-activation did not alter behavioral discrimination between safety (CS-1 and CS-2) cues and a threatening (CS+) cue (two-way repeated measures ANOVA, manipulation × CS, F < 1, p = 0.647; main effect of CS type, F2,12 = 32.3, p < 0.001, η2 = 0.619). b There was a trend towards flattening of the blood pressure (MAP) discrimination between safety cues and a threatening cue following over-activation (two-way repeated measures ANOVA, manipulation × CS, F2,12 = 3.8, p = 0.054; main effect of CS type, F2,12 = 19.5, p < 0.001, η2 = 0.382). c sgACC/25 over-activation elevated baseline VS (two-way repeated measures ANOVA, manipulation × CS, F < 1, p = 0.909; main effect of manipulation, F1,6 = 8.4, p = 0.027, η2 = 0.307). d sgACC/25 over-activation also elevated baseline blood pressure (two-way repeated measures ANOVA, manipulation × CS, F2,12 = 2.5, p = 0.124; main effect of manipulation, F1,6 = 22.7, p = 0.003, η2 = 0.062). e Trace showing mean blood pressure responses during the baseline, CS, US and recovery (R) phases of the CS+ trial. The recovery period was defined as the 10s period following termination of the US+. sgACC/25 over-activation slowed the decline in blood pressure (measured as a ratio of the blood pressure to the final second of the US+, inset; two-way repeated measures ANOVA, manipulation × time, F9,54 = 3.0, p = 0.005, η2 = 0.049). Source data are provided as a Source Data file.
