Fig. 2: Upregulation of baseline peripheral blood lipid mediators in DMARD non-responders. | Nature Communications

Fig. 2: Upregulation of baseline peripheral blood lipid mediators in DMARD non-responders.

From: Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Fig. 2

Peripheral blood was collected in patients DMARD responders (Resp) and DMARD non-responders (Non-Resp) prior to DMARD treatment initiation. Peripheral blood lipid mediator profiles were established in accordance with published criteria including matching retention time and MS/MS fragmentation spectra. Pathway analysis for the differential expression of mediators from the (top panel) DHA and n-3 DPA, and (bottom panel) EPA and AA bioactive metabolomes in Non-Resp when compared to Resp. Statistical differences between the normalised concentrations (expressed as the fold change) of the lipid mediators from the Non-Resp and Resp groups were determined using a two-sided t test followed by a multiple comparison correction using Benjamini–Hochberg procedure. Up- or downregulated mediators are denoted with using upward and downward facing triangles, respectively, and on changes of the node’s size. Bolded mediators represent statistical differences between the two groups when adjusted p value <0.05. Results are representative of n =  66 for Resp and n =  44 Non-Resp. Source data are provided as a Source data file.

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