Fig. 6: USP52–CtIP pathway is critical for enhancing chemotherapy of osteosarcoma cancer cells in vivo. | Nature Communications

Fig. 6: USP52–CtIP pathway is critical for enhancing chemotherapy of osteosarcoma cancer cells in vivo.

From: USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

Fig. 6

a–c Control or USP52-depleted U2OS cells stably expressing control vector, WT or 2KR mutant of CtIP were subcutaneously injected into the flank of NOD-SCID mice. Mice were treated with saline or olaparib (50 mg/kg i.p. 3 days × 6 times). Tumor images (a), tumor weight (b), and tumor volume (c) were then assessed. Data points in represent (mean ± SEM) are shown from n = 5 biologically independent samples by two-sided unpaired t test. d Working model of CtIP regulation by USP52.

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