Fig. 1: Selection of sybodies against SARS-CoV-2 RBD. | Nature Communications

Fig. 1: Selection of sybodies against SARS-CoV-2 RBD.

From: Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Fig. 1: Selection of sybodies against SARS-CoV-2 RBD.The alternative text for this image may have been generated using AI.

a Sybody selection statistics for the three different libraries. b Radial phylogenetic tree of all unique binders identified in this study. Sequence alignment was performed using PROMAL3D and the phylogenetic tree was construct using the maximum likelihood (ML) analysis in MEGA. Two sybodies (76 and 88), expected to stem from the convex library, were found to belong to the loop library, presumably due to a spill-over during the selection procedure.

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