Fig. 5: Cryo-EM reconstruction of SARS-CoV-2 spike bound to Sb23.

a Locally sharpened Coulomb potential map and cartoon model of Sb23 bound to the spike protein in the “1-up” conformation and cartoon model of Sb23-bound spike. b Locally sharpened Coulomb potential map and cartoon model of Sb23 bound to the spike protein in the “2-up” conformation.