Fig. 6: Top view of cryo-EM reconstruction of SARS-CoV-2 spike bound to Sb23 and modeling of the structural basis for Sb23-based blockage of SARS-CoV-2 spike binding to ACE2.

a Top view of locally sharpened Coulomb potential map and cartoon model of Sb23 bound to the spike protein in the “1-up” conformation b Top view of locally sharpened Coulomb potential map and cartoon model of Sb23 bound to the spike protein in the “2-up” conformation. c Cartoon model of Sb23-bound Spike in the “1-up” (left) “2-up” (right) conformation showing how ACE2 binding is blocked by Sb23 bound to the RBD in the “up” conformation as well as Sb23 bound to the neighboring RBD in the down conformation.