Fig. 7: Model III simulations are broadly consistent with experimental data.
From: The desensitization pathway of GABAA receptors, one subunit at a time
a–h Representative currents for the indicated constructs, in black, are overlaid with their simulation counterparts in red. Note the changes in timescales. i–l Bar graphs summarizing the experimental data (in black) vs the simulations (in red) for the indicated concatemers on the kinetics of the fast (panel i) and slow (panel j) desensitization components, the relative amplitude of the fast component (panel k) and the residual current after a 1 min long application of 10 mM GABA (panel l). Experimental data are shown as means (bar graphs) and standard deviations (error bars), with individual data points indicated as circles. See Supplementary Table 1 for numerical experimental values, the number of cells and number of independent series of experiments; and Supplementary Table 3 for the numerical values of parameters.
