Fig. 1: GWAS conditional on 23S rRNA mutations and dataset demonstrates decreased confounding and increased power. | Nature Communications

Fig. 1: GWAS conditional on 23S rRNA mutations and dataset demonstrates decreased confounding and increased power.

From: Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae

Fig. 1: GWAS conditional on 23S rRNA mutations and dataset demonstrates decreased confounding and increased power.The alternative text for this image may have been generated using AI.

Each variant is plotted using negative log10-transformed p-values, calculated using likelihood-ratio tests, for the association with azithromycin MICs in unconditional and conditional GWASes. Genetic linkage measured by r2 to 23S rRNA mutations A2059G and C2611T is colored for significant variants as indicated on the right, ranging from 0 (blue) to 0.5 (white) to 1 (red). Variants associated with previously experimentally verified resistance mechanisms in the mtrR and mtrCDE promoters and coding regions are denoted using diamonds. Bonferroni thresholds, calculated using the number of unique patterns, for both GWASes are depicted using a gray dashed line at 3.38 × 10−7. Plot axes are limited to highlight variants associated with lower-level resistance; as a result, the highly significant 23S rRNA substitutions and mtrC indel mutations7 are not shown.

Back to article page