Table 1 Macrolide MICs of laboratory strain 28Bl and two isogenic derivatives confirms increased macrolide resistance conferred by RplD G70D.

From: Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae

Isolate

Azithromycin MIC (µg/mL)

Clarithromycin MIC (µg/mL)

Erythromycin MIC (µg/mL)

28Bl

0.094

0.25

0.38

28Bl RplDG70D (C5)

0.25 (2.66×)

1.5 (6×)

1.5 (3.94×)

28Bl RplDG70D (E9)

0.38 (4.04×)

1.5 (6×)

1.0 (2.63×)

  1. Fold change relative to baseline is shown in parentheses. MICs were measured once for each isogenic derivative using Etest strips placed onto GCB agar plates supplemented with 1% IsoVitaleX.
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