Fig. 1: Design of light-induced PANAC conjugation enables modular functionalization of small molecules and native biomolecules in temporal control. | Nature Communications

Fig. 1: Design of light-induced PANAC conjugation enables modular functionalization of small molecules and native biomolecules in temporal control.

From: Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation

Fig. 1: Design of light-induced PANAC conjugation enables modular functionalization of small molecules and native biomolecules in temporal control.The alternative text for this image may have been generated using AI.

a o-Nitrobenzyl alcohol (o-NBA) was designed as molecular plugin and amide formations, as general linkage to rapidly access diverse reactants as modular units, and primary amines as straightforward click handle for PANAC photoclick reaction in vitro and in living systems. b Diverse applications of this PANAC photoclick chemistry.

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