Fig. 2: Scope for asymmetric synthesis of trisubstituted allenes 3 catalyzed by CPA catalyst (S)-B2. | Nature Communications

Fig. 2: Scope for asymmetric synthesis of trisubstituted allenes 3 catalyzed by CPA catalyst (S)-B2.

From: Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies

Fig. 2

Unless otherwise noted, reactions were performed with 1 (0.15 mmol), 2 (0.1 mmol), (S)-B2 catalyst (0.01 mmol) and 3 Å MS (100 mg) in CCl4 (0.5 mL) at room temperature for 24 h. Yields were isolated yields of allenes 3. Dr values were determined by crude 1H NMR analysis. Ee values were determined by HPLC analysis on a chiral stationary phase. Ar = 3,5-dimethoxyphenyl.

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